Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst
Pichromene 1 is a potential anti-cancer substance that is being studied
for treatment of chronic leukemia. In this paper have been developed
method for synthesis of pichrmene 1 and its analogs by condensation
between substituted salicylaldehyde and β-nitrostyrene derivatives under
different conditions (solvent, reaction time, temperature and
catalyst…). The research results showed that in toluene, at a
temperature of 800C, with acid L-pipecolic as catalyst, the yield of
pichromenes reached 82% after 24h. The structure of the products was
determined by the data of 1H-NMR and 13C-NMR spectroscopy. .
| Title: | Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| Authors: | Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng |
| Issue Date: | 2013 |
| Publisher: | H. : ĐHQGHN |
| Citation: | 7 tr. |
| Abstract: | Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. . |
| URI: | http://repository.vnu.edu.vn/handle/11126/13124 |
| Appears in Collections: | Natural Sciences and Technology |
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